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On the Cover: Genome-wide screens of differentially expressed genes will be crucial in diverse fields of plant biology in the coming millennium. The fluorescent differential display technique provides us with high reproducibility and high throughput for such screens by utilization of modified fluorescent-labeled primers and fluorescent DNA sequencers. Comparing mRNA fingerprints of the wild type and the phyA mutant of Arabidopsis with and without light irradiation, Kuno et al. (pp. 15-24) have carried out a large-scale screen using this technique and identified 15 phytochrome A-regulated genes from over 30,000 displayed bands, which would cover the majority of expressed mRNA species in Arabidopsis.
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