Plant Physiol. Drug Metab Dispos
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Plant Physiology 92:1081-1085 (1990)
© 1990 American Society of Plant Biologists

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Metabolism and Enzymology

A Mutation Causing Imidazolinone Resistance Maps to the Csr1 Locus of Arabidopsis thaliana1

George W. Haughn and Christopher R. Somerville

Department of Biology, University of Saskatchewan, Saskatoon, SK, Canada S7N 0W0, MSU-DOE Plant Research Laboratory, Michigan State University, East Lansing, Michigan 48824

A mutant of Arabidopsis thaliana, two hundred times more resistant to the imidazolinone herbicide imazapyr than wild-type plants, was isolated by direct selection of seedlings from a mutagenized population. Genetic analysis showed that resistance is due to a single dominant nuclear mutation that could not be separated by recombination from a mutation in the CSR1 gene encoding acetohydroxy acid synthase. Acetohydroxy acid synthase activity in extracts isolated from the mutant was 1000-fold more resistant to inhibition by imazapyr than that of the wild type. The resistant enzyme activity cosegregated with whole plant resistance. These data strongly suggest that the mutation is an allele of CSR1 encoding an imazapyr-resistant AHAS.

1 This work was supported in part by grants from the Natural Science and Engineering Research Council of Canada (No. OGP0036718) and a grant from the National Science Foundation (No. PCM8351595).




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